FFR-Guided PCI VS CABG for Multivessel Coronary Artery Disease: Lessons from FAME 3
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Introduction
Fractional flow reserve (FFR) has now become widely used in percutaneous coronary intervention (PCI) as it gives more accurate information about the physiological significance of the coronary lesions (1). Studied in the Fractional Flow Reserve V ersus Angiography for Multivessel Evaluation (FAME) trial (2), FFR-guided PCI was proven to have better outcomes than angiography-guided PCI for managing multivessel coronary artery disease (CAD) (2). Subsequently, the FAME 3 trial was conducted to assess the non-inferiority of FFR- guided PCI to coronary artery bypass graft (CABG) surgery in the management of multivessel CAD (3).